Tissue expression of TMC1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TMC1
Gene description	Transmembrane channel-like 1
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cervix, uterine)
GTEx:	Tissue enhanced (esophagus, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, testis)

GENE INFORMATION
Gene name	TMC1 (HGNC Symbol)
Synonyms	DFNA36, DFNB11, DFNB7
Description	Transmembrane channel-like 1 (HGNC Symbol)
Entrez gene summary	This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	72521801 - 72836351
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165091 (version 83.38)
Entrez gene	117531
UniProt	Q8TDI8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDI8
Antibodypedia	TMC1 antibodies

PROTEIN BROWSER

TMC1-001	TMC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC1-001 ENSP00000297784 ENST00000297784	Q8TDI8 [Direct mapping] Transmembrane channel-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0032426 [stereocilium bundle tip] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0060005 [vestibular reflex] GO:0060117 [auditory receptor cell development] GO:0070588 [calcium ion transmembrane transport] Show all	760 aa 87.8 kDa	No	9
TMC1-201 ENSP00000341433 ENST00000340019	Q8TDI8 [Direct mapping] Transmembrane channel-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Show all	GO:0016021 [integral component of membrane] Show all	760 aa 87.8 kDa	No	9