Expression of GKAP1 in cancer - Summary - The Human Protein Atlas

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GKAP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GKAP1
Gene description	G kinase anchoring protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA035117 , HPA035118
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035117	HPA035118

GENE INFORMATION
Gene name	GKAP1 (HGNC Symbol)
Synonyms	FKSG21, GKAP42
Description	G kinase anchoring protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	9
Cytoband	q21.32
Chromosome location (bp)	83739421 - 83829516
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165113 (version 83.38)
Entrez gene	80318
UniProt	Q5VSY0 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VSY0
Antibodypedia	GKAP1 antibodies

PROTEIN BROWSER

GKAP1-001	GKAP1-002	GKAP1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GKAP1-001 ENSP00000365550 ENST00000376371	Q5VSY0 [Direct mapping] G kinase-anchoring protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0007165 [signal transduction] Show all	366 aa 42.1 kDa	No	0
GKAP1-002 ENSP00000365544 ENST00000376365	Q5VSY0 [Direct mapping] G kinase-anchoring protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0007165 [signal transduction] Show all	315 aa 36.1 kDa	No	0
GKAP1-007 ENSP00000417621 ENST00000485742	C9J9D2 [Direct mapping] G kinase-anchoring protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0007165 [signal transduction] Show all	54 aa 5.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.