Expression of DYNLT3 in cancer - Summary - The Human Protein Atlas

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DYNLT3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DYNLT3
Gene description	Dynein, light chain, Tctex-type 3
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplamic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003938
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003938

GENE INFORMATION
Gene name	DYNLT3 (HGNC Symbol)
Synonyms	TCTE1L, TCTEX1L
Description	Dynein, light chain, Tctex-type 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Chromosome	X
Cytoband	p11.4
Chromosome location (bp)	37836757 - 37847637
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165169 (version 83.38)
Entrez gene	6990
UniProt	P51808 (UniProt - Evidence at protein level)
neXtProt	NX_P51808
Antibodypedia	DYNLT3 antibodies

PROTEIN BROWSER

DYNLT3-001	DYNLT3-002	DYNLT3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DYNLT3-001 ENSP00000367841 ENST00000378578	P51808 [Direct mapping] Dynein light chain Tctex-type 3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005868 [cytoplasmic dynein complex] GO:0005874 [microtubule] GO:0006810 [transport] GO:0007067 [mitotic nuclear division] GO:0007346 [regulation of mitotic cell cycle] GO:0008152 [metabolic process] GO:0042802 [identical protein binding] GO:0051301 [cell division] Show all	116 aa 13.1 kDa	No	0
DYNLT3-002 ENSP00000402695 ENST00000432389	F2Z328 [Direct mapping] Dynein light chain Tctex-type 3 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.4 kDa	Yes	0
DYNLT3-003 ENSP00000367844 ENST00000378581	A6NGJ0 [Direct mapping] Dynein light chain Tctex-type 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 17 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.