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Most testicular cancer and several gliomas, colorectal, breast and ovarian cancers showed moderate cytoplasmic positivity.
Melanomas, urothelial, gastric and pancreatic cancers showed moderate to strong cytoplasmic staining. Remaining cancer tissues were generally weakly stained or negative.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]