Expression of CARD19 in cancer - Summary - The Human Protein Atlas

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CARD19

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CARD19
Gene description	Caspase recruitment domain family, member 19
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA010921 , HPA010990 , HPA038297
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and glioma (unfavourable).
Liver cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010921	HPA010990	HPA038297

GENE INFORMATION
Gene name	CARD19 (HGNC Symbol)
Synonyms	bA370F5.1, BinCARD, C9orf89, MGC11115
Description	Caspase recruitment domain family, member 19 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	93096218 - 93113283
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165233 (version 83.38)
Entrez gene	84270
UniProt	Q96LW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96LW7
Antibodypedia	CARD19 antibodies

PROTEIN BROWSER

CARD19-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARD19-001 ENSP00000364613 ENST00000375464	Q96LW7 [Direct mapping] Bcl10-interacting CARD protein A0A024R248 [Target identity:100%; Query identity:100%] Chromosome 9 open reading frame 89, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050700 [CARD domain binding] Show all	183 aa 20.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.