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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AQP3
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AQP3

Gene description

Aquaporin 3 (Gill blood group)

Protein class

Blood group antigen proteins
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RT4, U-266/70, U-266/84)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most epithelial and glandular cells, including renal collecting ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA014924
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PROGNOSTIC SUMMARY

Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY

HPA014924

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong membranous staining in squamous cell carcinomas. Additional staining in a few other adenocarcinomas. Other cancer tissues were negative.

GENE INFORMATION

Gene name

AQP3 (HGNC Symbol)

Synonyms

GIL

Description

Aquaporin 3 (Gill blood group) (HGNC Symbol)

Entrez gene summary

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

33441154 - 33447611

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165272 (version 83.38)

Entrez gene

360

UniProt

Q92482 (UniProt - Evidence at transcript level)

neXtProt

NX_Q92482

Antibodypedia

AQP3 antibodies

PROTEIN BROWSER

AQP3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AQP3-001
ENSP00000297991
ENST00000297991
Q92482 [Direct mapping]
Aquaporin-3
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Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002684 [positive regulation of immune system process]
GO:0003091 [renal water homeostasis]
GO:0005215 [transporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009992 [cellular water homeostasis]
GO:0015204 [urea transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0015840 [urea transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0032526 [response to retinoic acid]
GO:0033280 [response to vitamin D]
GO:0034220 [ion transmembrane transport]
GO:0042476 [odontogenesis]
GO:0045616 [regulation of keratinocyte differentiation]
GO:0051592 [response to calcium ion]
GO:0055085 [transmembrane transport]
GO:0070295 [renal water absorption]
GO:0071918 [urea transmembrane transport]
Show all
292 aa
31.5 kDa
No 6

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