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Strong membranous staining in squamous cell carcinomas. Additional staining in a few other adenocarcinomas. Other cancer tissues were negative.
GENE INFORMATION
Gene name
AQP3 (HGNC Symbol)
Synonyms
GIL
Description
Aquaporin 3 (Gill blood group) (HGNC Symbol)
Entrez gene summary
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]