Expression of MELK in cancer - Summary - The Human Protein Atlas

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MELK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MELK
Gene description	Maternal embryonic leucine zipper kinase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA017214
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Lung cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017214

GENE INFORMATION
Gene name	MELK (HGNC Symbol)
Synonyms	KIAA0175
Description	Maternal embryonic leucine zipper kinase (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p13.2
Chromosome location (bp)	36572862 - 36677683
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165304 (version 83.38)
Entrez gene	9833
UniProt	Q14680 (UniProt - Evidence at protein level)
neXtProt	NX_Q14680
Antibodypedia	MELK antibodies

PROTEIN BROWSER

MELK-001	MELK-005	MELK-009	MELK-010	MELK-201	MELK-202	MELK-203	MELK-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MELK-001 ENSP00000298048 ENST00000298048	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	651 aa 74.6 kDa	No	1
MELK-005 ENSP00000487536 ENST00000495529	A0A0D9SGI4 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	215 aa 24.7 kDa	No	1
MELK-009 ENSP00000439184 ENST00000536987	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	520 aa 59.6 kDa	No	1
MELK-010 ENSP00000445452 ENST00000545008	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	580 aa 66.4 kDa	No	0
MELK-201 ENSP00000443550 ENST00000536329	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	580 aa 66.5 kDa	No	1
MELK-202 ENSP00000439792 ENST00000536860	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	603 aa 69.1 kDa	No	1
MELK-203 ENSP00000437804 ENST00000541717	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	610 aa 70.1 kDa	No	1
MELK-204 ENSP00000441596 ENST00000543751	Q14680 [Direct mapping] Maternal embryonic leucine zipper kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008283 [cell proliferation] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030097 [hemopoiesis] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0061351 [neural precursor cell proliferation] Show all	619 aa 71.2 kDa	No	1

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The Human Protein Atlas

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