Expression of OTUD1 in cancer - Summary - The Human Protein Atlas

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OTUD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OTUD1
Gene description	OTU deubiquitinase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, SiHa)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038504
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038504

GENE INFORMATION
Gene name	OTUD1 (HGNC Symbol)
Synonyms	DUBA7, OTDC1
Description	OTU deubiquitinase 1 (HGNC Symbol)
Entrez gene summary	Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Chromosome	10
Cytoband	p12.2
Chromosome location (bp)	23439458 - 23442390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165312 (version 83.38)
Entrez gene	220213
UniProt	Q5VV17 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VV17
Antibodypedia	OTUD1 antibodies

PROTEIN BROWSER

OTUD1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTUD1-001 ENSP00000365678 ENST00000376495	Q5VV17 [Direct mapping] OTU domain-containing protein 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004843 [ubiquitin-specific protease activity] GO:0070536 [protein K63-linked deubiquitination] Show all	481 aa 51.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.