Expression of TSHR in cancer - Summary - The Human Protein Atlas

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TSHR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TSHR
Gene description	Thyroid stimulating hormone receptor
Protein class	Cancer-related genes Disease related genes FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (MOLT-4, SCLC-21H, U-266/70)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. CAB000473
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB000473

GENE INFORMATION
Gene name	TSHR (HGNC Symbol)
Synonyms	LGR3
Description	Thyroid stimulating hormone receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Chromosome	14
Cytoband	q31.1
Chromosome location (bp)	80954989 - 81146302
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165409 (version 83.38)
Entrez gene	7253
UniProt	P16473 (UniProt - Evidence at protein level)
neXtProt	NX_P16473
Antibodypedia	TSHR antibodies

PROTEIN BROWSER

TSHR-001	TSHR-003	TSHR-004	TSHR-005	TSHR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSHR-001 ENSP00000441235 ENST00000541158	A0A0A0MTJ0 [Direct mapping] Thyrotropin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004996 [thyroid-stimulating hormone receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0008344 [adult locomotory behavior] GO:0008528 [G-protein coupled peptide receptor activity] GO:0009755 [hormone-mediated signaling pathway] GO:0016021 [integral component of membrane] GO:0030183 [B cell differentiation] GO:0038194 [thyroid-stimulating hormone signaling pathway] GO:0040012 [regulation of locomotion] GO:0040018 [positive regulation of multicellular organism growth] GO:0060119 [inner ear receptor cell development] GO:0060122 [inner ear receptor stereocilium organization] GO:0071542 [dopaminergic neuron differentiation] GO:0090103 [cochlea morphogenesis] Show all	764 aa 86.8 kDa	Yes	7
TSHR-003 ENSP00000340113 ENST00000342443	P16473 [Direct mapping] Thyrotropin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004996 [thyroid-stimulating hormone receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008528 [G-protein coupled peptide receptor activity] GO:0009755 [hormone-mediated signaling pathway] GO:0038194 [thyroid-stimulating hormone signaling pathway] GO:0043235 [receptor complex] Show all	253 aa 28.4 kDa	Yes	0
TSHR-004 ENSP00000451202 ENST00000554263	Q0VAP8 [Direct mapping] TSHR protein; Thyrotropin receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Show all	GO:0004996 [thyroid-stimulating hormone receptor activity] GO:0005515 [protein binding] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0008528 [G-protein coupled peptide receptor activity] GO:0009755 [hormone-mediated signaling pathway] GO:0016021 [integral component of membrane] GO:0038194 [thyroid-stimulating hormone signaling pathway] Show all	231 aa 26 kDa	Yes	0
TSHR-005 ENSP00000450549 ENST00000554435	P16473 [Direct mapping] Thyrotropin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0004996 [thyroid-stimulating hormone receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008528 [G-protein coupled peptide receptor activity] GO:0009755 [hormone-mediated signaling pathway] GO:0038194 [thyroid-stimulating hormone signaling pathway] GO:0043235 [receptor complex] Show all	274 aa 30.8 kDa	Yes	0
TSHR-201 ENSP00000298171 ENST00000298171	A0A0A0MTJ0 [Direct mapping] Thyrotropin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0008528 [G-protein coupled peptide receptor activity] GO:0009755 [hormone-mediated signaling pathway] GO:0016021 [integral component of membrane] GO:0038194 [thyroid-stimulating hormone signaling pathway] Show all	764 aa 86.8 kDa	Yes	7

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