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CFL2

GENERAL INFORMATION

Gene name

 CFL2

Gene description

 Cofilin 2 (muscle)

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in muscle tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA045599
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA045599

GENE INFORMATION

Gene name

 CFL2 (HGNC Symbol)

Synonyms

 NEM7

Description

 Cofilin 2 (muscle) (HGNC Symbol)

Entrez gene summary

 This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

Chromosome

 14

Cytoband

 q13.1

Chromosome location (bp)

 34706769 - 34714823

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165410 (version 83.38)

Entrez gene

 1073

UniProt

 Q9Y281 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y281

Antibodypedia

 CFL2 antibodies

PROTEIN BROWSER
CFL2-001
CFL2-002
CFL2-005
CFL2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CFL2-001
ENSP00000298159
ENST00000298159
Q9Y281 [Direct mapping]
Cofilin-2
Q549N0 [Target identity:100%; Query identity:100%]
Cofilin 2 (Muscle), isoform CRA_a; Cofilin 2 (Muscle), isoform CRA_c; Cofilin isoform; cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNA
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007015 [actin filament organization]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030042 [actin filament depolymerization]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0031674 [I band]
GO:0045214 [sarcomere organization]
GO:0046716 [muscle cell cellular homeostasis]
GO:0070062 [extracellular exosome]
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 166 aa
18.7 kDa 		No 0
CFL2-002
ENSP00000340635
ENST00000341223
Q9Y281 [Direct mapping]
Cofilin-2
Q549N0 [Target identity:100%; Query identity:100%]
Cofilin 2 (Muscle), isoform CRA_a; Cofilin 2 (Muscle), isoform CRA_c; Cofilin isoform; cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNA
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0031674 [I band]
GO:0070062 [extracellular exosome]
Show all
 166 aa
18.7 kDa 		No 0
CFL2-005
ENSP00000452451
ENST00000555765
Q9Y281 [Direct mapping]
Cofilin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0031674 [I band]
GO:0070062 [extracellular exosome]
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 149 aa
16.9 kDa 		No 0
CFL2-006
ENSP00000452188
ENST00000556161
Q9Y281 [Direct mapping]
Cofilin-2
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0031674 [I band]
GO:0070062 [extracellular exosome]
Show all
 149 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.