Expression of INPPL1 in cancer - Summary - The Human Protein Atlas

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INPPL1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INPPL1
Gene description	Inositol polyphosphate phosphatase-like 1
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA037601
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037601

GENE INFORMATION
Gene name	INPPL1 (HGNC Symbol)
Synonyms	SHIP2
Description	Inositol polyphosphate phosphatase-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	72223701 - 72239105
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165458 (version 83.38)
Entrez gene	3636
UniProt	O15357 (UniProt - Evidence at protein level)
neXtProt	NX_O15357
Antibodypedia	INPPL1 antibodies

PROTEIN BROWSER

INPPL1-001	INPPL1-002	INPPL1-003	INPPL1-005	INPPL1-006	INPPL1-013	INPPL1-014	INPPL1-015	INPPL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INPPL1-001 ENSP00000298229 ENST00000298229	O15357 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001958 [endochondral ossification] GO:0002376 [immune system process] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006006 [glucose metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006897 [endocytosis] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010629 [negative regulation of gene expression] GO:0016787 [hydrolase activity] GO:0017124 [SH3 domain binding] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0032868 [response to insulin] GO:0042169 [SH2 domain binding] GO:0043647 [inositol phosphate metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0097178 [ruffle assembly] Show all	1258 aa 138.6 kDa	No	0
INPPL1-002 ENSP00000444619 ENST00000538751	O15357 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001958 [endochondral ossification] GO:0002376 [immune system process] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006897 [endocytosis] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0016787 [hydrolase activity] GO:0017124 [SH3 domain binding] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0042169 [SH2 domain binding] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	1016 aa 113.2 kDa	No	0
INPPL1-003 ENSP00000440512 ENST00000543234	F5GWY9 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		18 aa 1.5 kDa	No	0
INPPL1-005 ENSP00000440018 ENST00000540329	F5GY16 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.6 kDa	No	0
INPPL1-006 ENSP00000444630 ENST00000537656	F5H588 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		34 aa 3.9 kDa	No	0
INPPL1-013 ENSP00000441094 ENST00000541752	H0YFZ4 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		197 aa 20.4 kDa	No	0
INPPL1-014 ENSP00000321775 ENST00000320683	H7BXR2 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	149 aa 16.4 kDa	No	0
INPPL1-015 ENSP00000440904 ENST00000540973	F5GYK9 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2 kDa	No	0
INPPL1-201 ENSP00000446360 ENST00000541756	A0A0A0MTP6 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0016787 [hydrolase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	1146 aa 126.5 kDa	No	0

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