Cell atlas - CRYL1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CRYL1
Gene description	Crystallin, lambda 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli. In addition localized to the plasma membrane & the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)
Additional location	In addition localized to the Golgi apparatus (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040403
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli. In addition localized to the plasma membrane & the Golgi apparatus.

Main location

Nucleus (approved), Nucleoli (approved)

Additional location

Golgi apparatus (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA040403	A-431	Nucleus
		Nucleoli
		Golgi apparatus
HPA040403	U-2 OS	Nucleus
		Nucleoli
		Plasma membrane
HPA040403	U-251 MG	Nucleus
		Nucleoli
		Plasma membrane

GENE INFORMATION
Gene name	CRYL1 (HGNC Symbol)
Synonyms	GDH, lambda-CRY, MGC149525, MGC149526
Description	Crystallin, lambda 1 (HGNC Symbol)
Entrez gene summary	The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	20403667 - 20525857
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165475 (version 83.38)
Entrez gene	51084
UniProt	Q9Y2S2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2S2
Antibodypedia	CRYL1 antibodies

PROTEIN BROWSER

CRYL1-001	CRYL1-002	CRYL1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYL1-001 ENSP00000298248 ENST00000298248	Q9Y2S2 [Direct mapping] Lambda-crystallin homolog V9HWG2 [Target identity:100%; Query identity:100%] Epididymis luminal protein 30 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0050104 [L-gulonate 3-dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	319 aa 35.4 kDa	No	0
CRYL1-002 ENSP00000372262 ENST00000382812	Q9Y2S2 [Direct mapping] Lambda-crystallin homolog A0A024RDM2 [Target identity:100%; Query identity:100%] Crystallin, lambda 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0050104 [L-gulonate 3-dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	297 aa 33.4 kDa	No	0
CRYL1-003 ENSP00000479908 ENST00000480748	A0A087WW38 [Direct mapping] Lambda-crystallin homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	148 aa 16.2 kDa	No	0