Cell atlas - HEPACAM - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HEPACAM

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	HEPACAM
Gene description	Hepatic and glial cell adhesion molecule
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017613
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017613	Hep G2	Vesicles
	HPA017613	U-2 OS	Vesicles
	HPA017613	U-251 MG	No staining

GENE INFORMATION
Gene name	HEPACAM (HGNC Symbol)
Synonyms	FLJ25530, GLIALCAM, hepaCAM
Description	Hepatic and glial cell adhesion molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	124919193 - 124936412
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165478 (version 83.38)
Entrez gene	220296
UniProt	Q14CZ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q14CZ8
Antibodypedia	HEPACAM antibodies

PROTEIN BROWSER

HEPACAM-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HEPACAM-001 ENSP00000298251 ENST00000298251	Q14CZ8 [Direct mapping] Hepatocyte cell adhesion molecule Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005911 [cell-cell junction] GO:0007050 [cell cycle arrest] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0034613 [cellular protein localization] GO:0040008 [regulation of growth] Show all	416 aa 46 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.