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MICU2

GENERAL INFORMATION

Gene name

 MICU2

Gene description

 Mitochondrial calcium uptake 2

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA045511
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045511

GENE INFORMATION

Gene name

 MICU2 (HGNC Symbol)

Synonyms

 EFHA1

Description

 Mitochondrial calcium uptake 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q12.11

Chromosome location (bp)

 21492691 - 21604214

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165487 (version 83.38)

Entrez gene

 221154

UniProt

 Q8IYU8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYU8

Antibodypedia

 MICU2 antibodies

PROTEIN BROWSER
MICU2-001
MICU2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MICU2-001
ENSP00000371811
ENST00000382374
Q8IYU8 [Direct mapping]
Calcium uptake protein 2, mitochondrial
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Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006851 [mitochondrial calcium ion transport]
GO:0034704 [calcium channel complex]
GO:0046982 [protein heterodimerization activity]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0051562 [negative regulation of mitochondrial calcium ion concentration]
GO:1990246 [uniplex complex]
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 434 aa
49.7 kDa 		No 0
MICU2-002
ENSP00000431792
ENST00000468222
A0A0A0MTD5 [Direct mapping]
Calcium uptake protein 2, mitochondrial
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 236 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.