Expression of TMEM63C in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TMEM63C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM63C
Gene description	Transmembrane protein 63C
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Karpas-707, SCLC-21H, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (adrenal gland, cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030657
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030657

GENE INFORMATION
Gene name	TMEM63C (HGNC Symbol)
Synonyms	C14orf171, CSC1, DKFZp434P0111, hsCSC1
Description	Transmembrane protein 63C (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	77116568 - 77259495
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165548 (version 83.38)
Entrez gene	57156
UniProt	Q9P1W3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9P1W3
Antibodypedia	TMEM63C antibodies

PROTEIN BROWSER

TMEM63C-001	TMEM63C-002	TMEM63C-003	TMEM63C-005	TMEM63C-006	TMEM63C-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM63C-001 ENSP00000298351 ENST00000298351	Q9P1W3 [Direct mapping] Calcium permeable stress-gated cation channel 1 A0A024R6B3 [Target identity:100%; Query identity:100%] Transmembrane protein 63C, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0098655 [cation transmembrane transport] Show all	806 aa 93.3 kDa	No	>9
TMEM63C-002 ENSP00000451398 ENST00000555338	G3V3S4 [Direct mapping] Calcium permeable stress-gated cation channel 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.5 kDa	No	0
TMEM63C-003 ENSP00000451404 ENST00000556514	G3V3S9 [Direct mapping] Calcium permeable stress-gated cation channel 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.9 kDa	No	0
TMEM63C-005 ENSP00000451842 ENST00000554766	G3V4J5 [Direct mapping] Calcium permeable stress-gated cation channel 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	164 aa 18.4 kDa	No	2
TMEM63C-006 ENSP00000451237 ENST00000554346	G3V3H0 [Direct mapping] Calcium permeable stress-gated cation channel 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.4 kDa	No	0
TMEM63C-007 ENSP00000450879 ENST00000557408	G3V2V1 [Direct mapping] Calcium permeable stress-gated cation channel 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.