Expression of NGB in cancer - Summary - The Human Protein Atlas

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NGB

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NGB
Gene description	Neuroglobin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer)
HPA (cell line):	Group enriched (RPMI-8226, SCLC-21H)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex, fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in adrenal gland and CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA042615 , HPA058596
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042615	HPA058596

GENE INFORMATION
Gene name	NGB
Synonyms
Description	Neuroglobin (HGNC Symbol)
Entrez gene summary	This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	77265483 - 77271312
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165553 (version 83.38)
Entrez gene	58157
UniProt	Q9NPG2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPG2
Antibodypedia	NGB antibodies

PROTEIN BROWSER

NGB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NGB-001 ENSP00000298352 ENST00000298352	Q9NPG2 [Direct mapping] Neuroglobin A0M8W9 [Target identity:100%; Query identity:100%] Neuroglobin; Neuroglobin, isoform CRA_a; cDNA, FLJ96443, Homo sapiens neuroglobin (NGB), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005344 [oxygen transporter activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0015671 [oxygen transport] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0043204 [perikaryon] GO:0046872 [metal ion binding] Show all	151 aa 16.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.