Expression of AKR1E2 in cancer - Summary - The Human Protein Atlas

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AKR1E2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AKR1E2
Gene description	Aldo-keto reductase family 1, member E2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (U-2197)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in seminiferous ducts and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA037822
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037822

GENE INFORMATION
Gene name	AKR1E2 (HGNC Symbol)
Synonyms	AKR1CL2, AKRDC1, MGC10612
Description	Aldo-keto reductase family 1, member E2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	10
Cytoband	p15.1
Chromosome location (bp)	4786629 - 4848062
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165568 (version 83.38)
Entrez gene	83592
UniProt	Q96JD6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JD6
Antibodypedia	AKR1E2 antibodies

PROTEIN BROWSER

AKR1E2-005	AKR1E2-006	AKR1E2-007	AKR1E2-009	AKR1E2-010	AKR1E2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKR1E2-005 ENSP00000431625 ENST00000487985	H0YCI2 [Direct mapping] 1,5-anhydro-D-fructose reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.1 kDa	No	0
AKR1E2-006 ENSP00000298375 ENST00000298375	Q96JD6 [Direct mapping] 1,5-anhydro-D-fructose reductase Show all	Enzymes ENZYME proteins Oxidoreductases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016491 [oxidoreductase activity] GO:0050571 [1,5-anhydro-D-fructose reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	320 aa 36.6 kDa	No	0
AKR1E2-007 ENSP00000435436 ENST00000533295	E9PK93 [Direct mapping] 1,5-anhydro-D-fructose reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	199 aa 22.8 kDa	No	0
AKR1E2-009 ENSP00000432947 ENST00000532248	Q96JD6 [Direct mapping] 1,5-anhydro-D-fructose reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016491 [oxidoreductase activity] GO:0050571 [1,5-anhydro-D-fructose reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	250 aa 28.7 kDa	No	0
AKR1E2-010 ENSP00000335603 ENST00000345253	Q96JD6 [Direct mapping] 1,5-anhydro-D-fructose reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016491 [oxidoreductase activity] GO:0050571 [1,5-anhydro-D-fructose reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	222 aa 25.7 kDa	No	0
AKR1E2-014 ENSP00000335034 ENST00000334019	Q96JD6 [Direct mapping] 1,5-anhydro-D-fructose reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0016491 [oxidoreductase activity] GO:0050571 [1,5-anhydro-D-fructose reductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	263 aa 30.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.