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SSX3

GENERAL INFORMATION

Gene name

 SSX3

Gene description

 Synovial sarcoma, X breakpoint 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (Karpas-707)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA045683
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045683

GENE INFORMATION

Gene name

 SSX3 (HGNC Symbol)

Synonyms

 CT5.3

Description

 Synovial sarcoma, X breakpoint 3 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48346428 - 48356707

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165584 (version 83.38)

Entrez gene

 10214

UniProt

 Q99909 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99909

Antibodypedia

 SSX3 antibodies

PROTEIN BROWSER
SSX3-001
SSX3-002
SSX3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSX3-001
ENSP00000298396
ENST00000298396
Q99909 [Direct mapping]
Protein SSX3
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 188 aa
21.7 kDa 		No 0
SSX3-002
ENSP00000366090
ENST00000376893
Q99909 [Direct mapping]
Protein SSX3
A0A024R1B1 [Target identity:100%; Query identity:100%]
Synovial sarcoma, X breakpoint 3, isoform CRA_a
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 170 aa
19.5 kDa 		No 0
SSX3-004
ENSP00000480427
ENST00000612497
A0A087WWQ6 [Direct mapping]
Protein SSX3
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
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 202 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.