Expression of PRPF18 in cancer - Summary - The Human Protein Atlas

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PRPF18

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRPF18
Gene description	Pre-mRNA processing factor 18
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA037599 , HPA047950
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037599	HPA047950

GENE INFORMATION
Gene name	PRPF18 (HGNC Symbol)
Synonyms	hPrp18
Description	Pre-mRNA processing factor 18 (HGNC Symbol)
Entrez gene summary	Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p13
Chromosome location (bp)	13586927 - 13630868
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165630 (version 83.38)
Entrez gene	8559
UniProt	Q99633 (UniProt - Evidence at protein level)
neXtProt	NX_Q99633
Antibodypedia	PRPF18 antibodies

PROTEIN BROWSER

PRPF18-001	PRPF18-002	PRPF18-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPF18-001 ENSP00000367835 ENST00000378572	Q99633 [Direct mapping] Pre-mRNA-splicing factor 18 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000350 [generation of catalytic spliceosome for second transesterification step] GO:0000386 [second spliceosomal transesterification activity] GO:0005634 [nucleus] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0071021 [U2-type post-spliceosomal complex] GO:0071048 [nuclear retention of unspliced pre-mRNA at the site of transcription] Show all	342 aa 39.9 kDa	No	0
PRPF18-002 ENSP00000367824 ENST00000320054	Q5T9P8 [Direct mapping] Pre-mRNA-splicing factor 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008380 [RNA splicing] Show all	167 aa 19.4 kDa	No	0
PRPF18-003 ENSP00000392142 ENST00000417658	Q5T9P7 [Direct mapping] Pre-mRNA-splicing factor 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005681 [spliceosomal complex] GO:0008380 [RNA splicing] Show all	249 aa 28.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.