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SOHLH1

GENERAL INFORMATION

Gene name

 SOHLH1

Gene description

 Spermatogenesis and oogenesis specific basic helix-loop-helix 1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (CACO-2, U-266/84)
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SOHLH1 (HGNC Symbol)

Synonyms

 bA100C15.3, bHLHe80, C9orf157, NOHLH, SPATA27, TEB2

Description

 Spermatogenesis and oogenesis specific basic helix-loop-helix 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 9. Mutations in this gene are associated with nonobstructive azoospermia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 135693407 - 135699528

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165643 (version 83.38)

Entrez gene

 402381

UniProt

 Q5JUK2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JUK2

Antibodypedia

 SOHLH1 antibodies

PROTEIN BROWSER
SOHLH1-001
SOHLH1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOHLH1-001
ENSP00000298466
ENST00000298466
Q5JUK2 [Direct mapping]
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
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Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
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GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0046983 [protein dimerization activity]
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 328 aa
34.5 kDa 		No 0
SOHLH1-201
ENSP00000404438
ENST00000425225
Q5JUK2 [Direct mapping]
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001541 [ovarian follicle development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0010468 [regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048477 [oogenesis]
Show all
 387 aa
40.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.