Fields »
ABOUT
HELP
BLOG
DDX21

GENERAL INFORMATION

Gene name

 DDX21

Gene description

 DEAD (Asp-Glu-Ala-Asp) box helicase 21

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and nucleolar expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036592 , HPA036593
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX21 (HGNC Symbol)

Synonyms

 GURDB, RH-II/GU

Description

 DEAD (Asp-Glu-Ala-Asp) box helicase 21 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 68956128 - 68985073

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165732 (version 83.38)

Entrez gene

 9188

UniProt

 Q9NR30 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR30

Antibodypedia

 DDX21 antibodies

PROTEIN BROWSER
DDX21-001
DDX21-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX21-001
ENSP00000346120
ENST00000354185
Q9NR30 [Direct mapping]
Nucleolar RNA helicase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009615 [response to virus]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0019843 [rRNA binding]
GO:0030515 [snoRNA binding]
GO:0043330 [response to exogenous dsRNA]
GO:0044822 [poly(A) RNA binding]
GO:0097322 [7SK snRNA binding]
Show all
 783 aa
87.3 kDa 		No 0
DDX21-201
ENSP00000480334
ENST00000620315
Q9NR30 [Direct mapping]
Nucleolar RNA helicase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0019843 [rRNA binding]
GO:0030515 [snoRNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0097322 [7SK snRNA binding]
Show all
 715 aa
79.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.