Expression of KIAA1462 in cancer - Summary - The Human Protein Atlas

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KIAA1462

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KIAA1462
Gene description	KIAA1462
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, LHCN-M2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA017956
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable) and renal cancer (unfavourable).
Stomach cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017956

GENE INFORMATION
Gene name	KIAA1462 (HGNC Symbol)
Synonyms	JCAD
Description	KIAA1462 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p11.23
Chromosome location (bp)	30012800 - 30115494
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165757 (version 83.38)
Entrez gene	57608
UniProt	Q9P266 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P266
Antibodypedia	KIAA1462 antibodies

PROTEIN BROWSER

KIAA1462-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIAA1462-002 ENSP00000364526 ENST00000375377	Q9P266 [Direct mapping] Junctional protein associated with coronary artery disease Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0007155 [cell adhesion] GO:0030054 [cell junction] Show all	1359 aa 148.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.