Expression of TMEM55B in cancer - Summary - The Human Protein Atlas

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TMEM55B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM55B
Gene description	Transmembrane protein 55B
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA048528
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048528

GENE INFORMATION
Gene name	TMEM55B (HGNC Symbol)
Synonyms	C14orf9, MGC26684
Description	Transmembrane protein 55B (HGNC Symbol)
Entrez gene summary	TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20457719 - 20461612
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165782 (version 83.38)
Entrez gene	90809
UniProt	Q86T03 (UniProt - Evidence at protein level)
neXtProt	NX_Q86T03
Antibodypedia	TMEM55B antibodies

PROTEIN BROWSER

TMEM55B-001	TMEM55B-003	TMEM55B-004	TMEM55B-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM55B-001 ENSP00000250489 ENST00000250489	Q86T03 [Direct mapping] Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	277 aa 29.5 kDa	No	2
TMEM55B-003 ENSP00000381102 ENST00000398020	Q86T03 [Direct mapping] Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0046856 [phosphatidylinositol dephosphorylation] Show all	284 aa 30.2 kDa	No	2
TMEM55B-004 ENSP00000452508 ENST00000556093	G3V5T5 [Direct mapping] Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 4.9 kDa	No	0
TMEM55B-007 ENSP00000451014 ENST00000553460	H0YJ90 [Direct mapping] Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	112 aa 12.5 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.