Fields »
ABOUT
HELP
BLOG
CASP7

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CASP7

Gene description

 Caspase 7, apoptosis-related cysteine peptidase

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CASP7 (HGNC Symbol)

Synonyms

 CMH-1, ICE-LAP3, MCH3

Description

 Caspase 7, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 113679162 - 113730907

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165806 (version 83.38)

Entrez gene

 840

UniProt

 P55210 (UniProt - Evidence at protein level)

neXtProt

 NX_P55210

Antibodypedia

 CASP7 antibodies

PROTEIN BROWSER
CASP7-001
CASP7-002
CASP7-003
CASP7-004
CASP7-005
CASP7-201
CASP7-202
CASP7-203
CASP7-204
CASP7-205

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP7-001
ENSP00000358324
ENST00000369318
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 303 aa
34.3 kDa 		No 0
CASP7-002
ENSP00000358321
ENST00000369315
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 303 aa
34.3 kDa 		No 0
CASP7-003
ENSP00000358337
ENST00000369331
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 253 aa
28 kDa 		No 0
CASP7-004
ENSP00000400094
ENST00000429617
Q5SVL2 [Direct mapping]
Caspase-7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 222 aa
24.8 kDa 		No 0
CASP7-005
ENSP00000298701
ENST00000345633
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 303 aa
34.3 kDa 		No 0
CASP7-201
ENSP00000358327
ENST00000369321
A0A0A0MRL7 [Direct mapping]
Caspase-7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0008234 [cysteine-type peptidase activity]
GO:0009411 [response to UV]
GO:0016485 [protein processing]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051402 [neuron apoptotic process]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 388 aa
43.7 kDa 		No 0
CASP7-202
ENSP00000398107
ENST00000452490
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 278 aa
31.6 kDa 		No 0
CASP7-203
ENSP00000478285
ENST00000614447
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 253 aa
28 kDa 		No 0
CASP7-204
ENSP00000480584
ENST00000621345
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 303 aa
34.3 kDa 		No 0
CASP7-205
ENSP00000478999
ENST00000621607
P55210 [Direct mapping]
Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008234 [cysteine-type peptidase activity]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0012501 [programmed cell death]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Show all
 336 aa
37.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.