Expression of CCDC186 in cancer - Summary - The Human Protein Atlas

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CCDC186

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC186
Gene description	Coiled-coil domain containing 186
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA014569 , HPA018019
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014569	HPA018019

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cytoplasmic and nuclear staining in all malignant tissues at variable intensity. Strongest staining was seen in melanomas, head and neck and endometrial cancers.

GENE INFORMATION
Gene name	CCDC186 (HGNC Symbol)
Synonyms	C10orf118, FLJ10188, FLJ35301
Description	Coiled-coil domain containing 186 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q25.3
Chromosome location (bp)	114120862 - 114174220
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165813 (version 83.38)
Entrez gene	55088
UniProt	Q7Z3E2 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z3E2
Antibodypedia	CCDC186 antibodies

PROTEIN BROWSER

CCDC186-001	CCDC186-002	CCDC186-003	CCDC186-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC186-001 ENSP00000415344 ENST00000428953	H0Y7V5 [Direct mapping] Coiled-coil domain-containing protein 186 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		436 aa 50.8 kDa	No	0
CCDC186-002 ENSP00000358292 ENST00000369286	A0A0C4DFU7 [Direct mapping] Coiled-coil domain-containing protein 186 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		211 aa 23.6 kDa	No	0
CCDC186-003 ENSP00000358291 ENST00000369285	A0A0C4DFU7 [Direct mapping] Coiled-coil domain-containing protein 186 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		211 aa 23.6 kDa	No	0
CCDC186-006 ENSP00000358293 ENST00000369287	Q7Z3E2 [Direct mapping] Coiled-coil domain-containing protein 186 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		898 aa 103.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.