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Several case of hepatocellular carcinomas showed cytoplasmic staining. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
CYP2C19 (HGNC Symbol)
Synonyms
CPCJ, CYP2C, P450IIC19
Description
Cytochrome P450, family 2, subfamily C, polypeptide 19 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process]