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ZFYVE1

GENERAL INFORMATION

Gene name

 ZFYVE1

Gene description

 Zinc finger, FYVE domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granualar pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA002898
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002898

GENE INFORMATION

Gene name

 ZFYVE1 (HGNC Symbol)

Synonyms

 DFCP1, KIAA1589, PPP1R172, TAFF1, ZNFN2A1

Description

 Zinc finger, FYVE domain containing 1 (HGNC Symbol)

Entrez gene summary

 The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 14

Cytoband

 q24.2

Chromosome location (bp)

 72969451 - 73027212

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165861 (version 83.38)

Entrez gene

 53349

UniProt

 Q9HBF4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBF4

Antibodypedia

 ZFYVE1 antibodies

PROTEIN BROWSER
ZFYVE1-001
ZFYVE1-002
ZFYVE1-003
ZFYVE1-004
ZFYVE1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZFYVE1-001
ENSP00000450742
ENST00000556143
Q9HBF4 [Direct mapping]
Zinc finger FYVE domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005795 [Golgi stack]
GO:0008270 [zinc ion binding]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0097629 [extrinsic component of omegasome membrane]
Show all
 777 aa
87.2 kDa 		No 0
ZFYVE1-002
ENSP00000326921
ENST00000318876
Q9HBF4 [Direct mapping]
Zinc finger FYVE domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005795 [Golgi stack]
GO:0008270 [zinc ion binding]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0097629 [extrinsic component of omegasome membrane]
Show all
 763 aa
85.6 kDa 		No 0
ZFYVE1-003
ENSP00000452232
ENST00000555072
Q9HBF4 [Direct mapping]
Zinc finger FYVE domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005795 [Golgi stack]
GO:0008270 [zinc ion binding]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0097629 [extrinsic component of omegasome membrane]
Show all
 362 aa
40.3 kDa 		No 0
ZFYVE1-004
ENSP00000377757
ENST00000394207
Q9HBF4 [Direct mapping]
Zinc finger FYVE domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000407 [pre-autophagosomal structure]
GO:0005515 [protein binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005795 [Golgi stack]
GO:0008270 [zinc ion binding]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0097629 [extrinsic component of omegasome membrane]
Show all
 362 aa
40.3 kDa 		No 0
ZFYVE1-005
ENSP00000452442
ENST00000553891
G3V5N8 [Direct mapping]
Zinc finger FYVE domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
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 789 aa
88.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.