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Most cancer tissues showed moderate cytoplasmic and/or nuclear immunoreactivity. Several lung cancers were weakly stained or negative.
GENE INFORMATION
Gene name
FRAT1
Synonyms
Description
Frequently rearranged in advanced T-cell lymphomas 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]