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ANKRD2

GENERAL INFORMATION

Gene name

 ANKRD2

Gene description

 Ankyrin repeat domain 2 (stretch responsive muscle)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (A-431, HaCaT, RPTEC TERT1)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in myocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040842 , HPA040884
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA040842
HPA040884

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 A few cases of endometrial, ovarian and thyroid cancers showed moderate to strong cytoplasmic and nuclear staining in a subset of tumor cells. Remaining malignant cells along with stromal cells were negative.

GENE INFORMATION

Gene name

 ANKRD2 (HGNC Symbol)

Synonyms

 ARPP

Description

 Ankyrin repeat domain 2 (stretch responsive muscle) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 97572499 - 97583884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165887 (version 83.38)

Entrez gene

 26287

UniProt

 Q9GZV1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV1

Antibodypedia

 ANKRD2 antibodies

PROTEIN BROWSER
ANKRD2-001
ANKRD2-002
ANKRD2-201
ANKRD2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANKRD2-001
ENSP00000359689
ENST00000370655
A0A0A0MRN9 [Direct mapping]
Ankyrin repeat domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
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 333 aa
37.1 kDa 		No 0
ANKRD2-002
ENSP00000403114
ENST00000455090
Q5T457 [Direct mapping]
Ankyrin repeat domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0043231 [intracellular membrane-bounded organelle]
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 300 aa
33.5 kDa 		No 0
ANKRD2-201
ENSP00000298808
ENST00000298808
Q9GZV1 [Direct mapping]
Ankyrin repeat domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000791 [euchromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0016605 [PML body]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0031674 [I band]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043422 [protein kinase B binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0061629 [RNA polymerase II sequence-specific DNA binding transcription factor binding]
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 327 aa
36.2 kDa 		No 0
ANKRD2-202
ENSP00000306163
ENST00000307518
Q9GZV1 [Direct mapping]
Ankyrin repeat domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000791 [euchromatin]
GO:0001817 [regulation of cytokine production]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0010832 [negative regulation of myotube differentiation]
GO:0016605 [PML body]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031432 [titin binding]
GO:0031674 [I band]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043422 [protein kinase B binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0061629 [RNA polymerase II sequence-specific DNA binding transcription factor binding]
GO:1902253 [regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000291 [regulation of myoblast proliferation]
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 360 aa
39.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.