Cell atlas - E2F7 - The Human Protein Atlas

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E2F7

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	E2F7
Gene description	E2F transcription factor 7
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA064866
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064866	HeLa	Nuclear speckles
	HPA064866	U-2 OS	Nuclear speckles
	HPA064866	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	E2F7
Synonyms
Description	E2F transcription factor 7 (HGNC Symbol)
Entrez gene summary	E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]
Chromosome	12
Cytoband	q21.2
Chromosome location (bp)	77021247 - 77065580
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165891 (version 83.38)
Entrez gene	144455
UniProt	Q96AV8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AV8
Antibodypedia	E2F7 antibodies

PROTEIN BROWSER

E2F7-001	E2F7-003	E2F7-004	E2F7-005	E2F7-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
E2F7-001 ENSP00000323246 ENST00000322886	Q96AV8 [Direct mapping] Transcription factor E2F7 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001890 [placenta development] GO:0002040 [sprouting angiogenesis] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0032466 [negative regulation of cytokinesis] GO:0032877 [positive regulation of DNA endoreduplication] GO:0042802 [identical protein binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060707 [trophoblast giant cell differentiation] GO:0060718 [chorionic trophoblast cell differentiation] GO:0070365 [hepatocyte differentiation] GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] Show all	911 aa 99.9 kDa	No	0
E2F7-003 ENSP00000448245 ENST00000550669	F8VSE7 [Direct mapping] Transcription factor E2F7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	693 aa 77.1 kDa	No	0
E2F7-004 ENSP00000393639 ENST00000416496	Q96AV8 [Direct mapping] Transcription factor E2F7 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001047 [core promoter binding] GO:0001890 [placenta development] GO:0002040 [sprouting angiogenesis] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008285 [negative regulation of cell proliferation] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0032466 [negative regulation of cytokinesis] GO:0032877 [positive regulation of DNA endoreduplication] GO:0042802 [identical protein binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060707 [trophoblast giant cell differentiation] GO:0060718 [chorionic trophoblast cell differentiation] GO:0070365 [hepatocyte differentiation] GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] Show all	728 aa 80.9 kDa	No	0
E2F7-005 ENSP00000449033 ENST00000547316	F8VXV5 [Direct mapping] Transcription factor E2F7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.3 kDa	No	0
E2F7-007 ENSP00000449284 ENST00000551058	H0YIF4 [Direct mapping] Transcription factor E2F7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	219 aa 25.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.