Expression of ARHGAP42 in cancer - Summary - The Human Protein Atlas

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ARHGAP42

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGAP42
Gene description	Rho GTPase activating protein 42
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA039924
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039924

GENE INFORMATION
Gene name	ARHGAP42 (HGNC Symbol)
Synonyms	FLJ32810, GRAF3
Description	Rho GTPase activating protein 42 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q22.1
Chromosome location (bp)	100687653 - 100991937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165895 (version 83.38)
Entrez gene	143872
UniProt	A6NI28 (UniProt - Evidence at protein level)
neXtProt	NX_A6NI28
Antibodypedia	ARHGAP42 antibodies

PROTEIN BROWSER

ARHGAP42-003	ARHGAP42-006	ARHGAP42-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP42-003 ENSP00000431776 ENST00000524892	E9PJK4 [Direct mapping] Rho GTPase-activating protein 42 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	840 aa 94.5 kDa	No	0
ARHGAP42-006 ENSP00000434304 ENST00000531183	H0YDU1 [Direct mapping] Rho GTPase-activating protein 42 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		230 aa 27.4 kDa	No	0
ARHGAP42-201 ENSP00000298815 ENST00000298815	A6NI28 [Direct mapping] Rho GTPase-activating protein 42 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	874 aa 98.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.