Expression of GYLTL1B in cancer - Summary - The Human Protein Atlas

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GYLTL1B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GYLTL1B
Gene description	Glycosyltransferase-like 1B
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, NTERA-2, T-47d)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA056621
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA056621

GENE INFORMATION
Gene name	GYLTL1B (HGNC Symbol)
Synonyms	FLJ35207, LARGE2, PP5656
Description	Glycosyltransferase-like 1B (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	45921621 - 45929096
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165905 (version 83.38)
Entrez gene	120071
UniProt	Q8N3Y3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3Y3
Antibodypedia	GYLTL1B antibodies

PROTEIN BROWSER

GYLTL1B-001	GYLTL1B-002	GYLTL1B-003	GYLTL1B-008	GYLTL1B-009	GYLTL1B-201	GYLTL1B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYLTL1B-001 ENSP00000385235 ENST00000401752	Q8N3Y3 [Direct mapping] Glycosyltransferase-like protein LARGE2 Xylosyltransferase LARGE2 Beta-1,3-glucuronyltransferase LARGE2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030145 [manganese ion binding] GO:0035269 [protein O-linked mannosylation] GO:0042285 [xylosyltransferase activity] GO:0046716 [muscle cell cellular homeostasis] Show all	721 aa 81.8 kDa	Yes	0
GYLTL1B-002 ENSP00000432869 ENST00000531526	Q8N3Y3 [Direct mapping] Glycosyltransferase-like protein LARGE2 Xylosyltransferase LARGE2 Beta-1,3-glucuronyltransferase LARGE2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002162 [dystroglycan binding] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030145 [manganese ion binding] GO:0035269 [protein O-linked mannosylation] GO:0042285 [xylosyltransferase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0046716 [muscle cell cellular homeostasis] Show all	721 aa 81.8 kDa	Yes	0
GYLTL1B-003 ENSP00000431932 ENST00000529052	E9PIZ2 [Direct mapping] Glycosyltransferase-like protein LARGE2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	690 aa 78.7 kDa	Yes	0
GYLTL1B-008 ENSP00000434325 ENST00000531847	H0YDU6 [Direct mapping] Glycosyltransferase-like protein LARGE2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 11.2 kDa	No	0
GYLTL1B-009 ENSP00000433328 ENST00000534410	H0YDB8 [Direct mapping] Glycosyltransferase-like protein LARGE2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 18.2 kDa	No	0
GYLTL1B-201 ENSP00000324570 ENST00000325468	Q8N3Y3 [Direct mapping] Glycosyltransferase-like protein LARGE2 Xylosyltransferase LARGE2 Beta-1,3-glucuronyltransferase LARGE2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030145 [manganese ion binding] GO:0035269 [protein O-linked mannosylation] GO:0042285 [xylosyltransferase activity] GO:0046716 [muscle cell cellular homeostasis] Show all	721 aa 81.8 kDa	Yes	0
GYLTL1B-202 ENSP00000445044 ENST00000536139	A0A0C4DGH7 [Direct mapping] Glycosyltransferase-like protein LARGE2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		257 aa 28.6 kDa	No	0

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The Human Protein Atlas

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