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PACSIN3

GENERAL INFORMATION

Gene name

 PACSIN3

Gene description

 Protein kinase C and casein kinase substrate in neurons 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA039480 , HPA043904
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA039480
HPA043904

GENE INFORMATION

Gene name

 PACSIN3 (HGNC Symbol)

Synonyms

 SDPIII

Description

 Protein kinase C and casein kinase substrate in neurons 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47177525 - 47186443

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165912 (version 83.38)

Entrez gene

 29763

UniProt

 Q9UKS6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKS6

Antibodypedia

 PACSIN3 antibodies

PROTEIN BROWSER
PACSIN3-002
PACSIN3-003
PACSIN3-004
PACSIN3-005
PACSIN3-006
PACSIN3-007
PACSIN3-008
PACSIN3-009
PACSIN3-010
PACSIN3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PACSIN3-002
ENSP00000298838
ENST00000298838
Q9UKS6 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0008289 [lipid binding]
GO:0019855 [calcium channel inhibitor activity]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
GO:0045806 [negative regulation of endocytosis]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051926 [negative regulation of calcium ion transport]
GO:0070062 [extracellular exosome]
GO:0097320 [membrane tubulation]
Show all
 424 aa
48.5 kDa 		No 0
PACSIN3-003
ENSP00000437252
ENST00000528462
A0A0C4DGG1 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 405 aa
46.5 kDa 		No 0
PACSIN3-004
ENSP00000431861
ENST00000524509
E9PJ33 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 69 aa
7.8 kDa 		No 0
PACSIN3-005
ENSP00000435638
ENST00000525725
E9PJ75 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 142 aa
16.2 kDa 		No 0
PACSIN3-006
ENSP00000435672
ENST00000530405
E9PJ33 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 69 aa
7.8 kDa 		No 0
PACSIN3-007
ENSP00000431924
ENST00000530513
E9PIZ6 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 48 aa
5.8 kDa 		No 0
PACSIN3-008
ENSP00000434521
ENST00000528201
E9PQ12 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 36 aa
4.3 kDa 		No 0
PACSIN3-009
ENSP00000434699
ENST00000531226
E9PNM9 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 148 aa
17 kDa 		No 0
PACSIN3-010
ENSP00000433962
ENST00000533686
H0YDM6 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005768 [endosome]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 76 aa
8.2 kDa 		No 0
PACSIN3-201
ENSP00000440945
ENST00000539589
Q9UKS6 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007010 [cytoskeleton organization]
GO:0008092 [cytoskeletal protein binding]
GO:0008289 [lipid binding]
GO:0019855 [calcium channel inhibitor activity]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
GO:0045806 [negative regulation of endocytosis]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051926 [negative regulation of calcium ion transport]
GO:0070062 [extracellular exosome]
GO:0097320 [membrane tubulation]
Show all
 424 aa
48.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.