Expression of SLC39A13 in cancer - Summary - The Human Protein Atlas

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SLC39A13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC39A13
Gene description	Solute carrier family 39 (zinc transporter), member 13
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043971
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable), renal cancer (favourable) and colorectal cancer (unfavourable).
Ovarian cancer p<0.001 Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043971

GENE INFORMATION
Gene name	SLC39A13 (HGNC Symbol)
Synonyms	FLJ25785
Description	Solute carrier family 39 (zinc transporter), member 13 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome.[provided by RefSeq, Mar 2010]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	47407132 - 47416501
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165915 (version 83.38)
Entrez gene	91252
UniProt	Q96H72 (UniProt - Evidence at protein level)
neXtProt	NX_Q96H72
Antibodypedia	SLC39A13 antibodies

PROTEIN BROWSER

SLC39A13-001	SLC39A13-003	SLC39A13-004	SLC39A13-005	SLC39A13-007	SLC39A13-008	SLC39A13-010	SLC39A13-011	SLC39A13-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A13-001 ENSP00000434290 ENST00000533076	G3V1B2 [Direct mapping] Solute carrier family 39 (Zinc transporter), member 13, isoform CRA_a; Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	325 aa 34 kDa	Yes	4
SLC39A13-003 ENSP00000437186 ENST00000524928	E9PNE7 [Direct mapping] Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	321 aa 33.8 kDa	Yes	3
SLC39A13-004 ENSP00000432499 ENST00000526614	K4DIA9 [Direct mapping] Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	248 aa 25.9 kDa	Yes	3
SLC39A13-005 ENSP00000435076 ENST00000527091	K4DIB5 [Direct mapping] Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	138 aa 14.6 kDa	Yes	2
SLC39A13-007 ENSP00000435845 ENST00000531974	E9PSA8 [Direct mapping] Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	140 aa 14.8 kDa	Yes	2
SLC39A13-008 ENSP00000434684 ENST00000531865	E9PNN7 [Direct mapping] Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	259 aa 27.4 kDa	Yes	4
SLC39A13-010 ENSP00000432302 ENST00000531419	E9PRH4 [Direct mapping] Zinc transporter ZIP13 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	218 aa 23 kDa	Yes	3
SLC39A13-011 ENSP00000346956 ENST00000354884	Q96H72 [Direct mapping] Zinc transporter ZIP13 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030173 [integral component of Golgi membrane] GO:0042803 [protein homodimerization activity] GO:0046873 [metal ion transmembrane transporter activity] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:0061448 [connective tissue development] GO:0071577 [zinc II ion transmembrane transport] Show all	364 aa 38.4 kDa	Yes	6
SLC39A13-012 ENSP00000354689 ENST00000362021	Q96H72 [Direct mapping] Zinc transporter ZIP13 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030173 [integral component of Golgi membrane] GO:0042803 [protein homodimerization activity] GO:0046873 [metal ion transmembrane transporter activity] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:0061448 [connective tissue development] GO:0071577 [zinc II ion transmembrane transport] Show all	371 aa 39 kDa	Yes	6

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