Expression of CLMN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLMN
Gene description	Calmin (calponin-like, transmembrane)
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (WM-115)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression, most abundant in glandular cells, renal tubules and respiratory epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA012634
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA012634

GENE INFORMATION
Gene name	CLMN (HGNC Symbol)
Synonyms	FLJ12383, KIAA0500, KIAA1188
Description	Calmin (calponin-like, transmembrane) (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	95181940 - 95319906
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165959 (version 83.38)
Entrez gene	79789
UniProt	Q96JQ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JQ2
Antibodypedia	CLMN antibodies

PROTEIN BROWSER

CLMN-001	CLMN-003	CLMN-005	CLMN-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLMN-001 ENSP00000298912 ENST00000298912	Q96JQ2 [Direct mapping] Calmin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0031175 [neuron projection development] Show all	1002 aa 111.7 kDa	No	1
CLMN-003 ENSP00000451705 ENST00000555336	G3V4C0 [Direct mapping] Calmin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	133 aa 14.5 kDa	No	0
CLMN-005 ENSP00000452305 ENST00000556441	G3V5E0 [Direct mapping] Calmin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	67 aa 7.7 kDa	No	1
CLMN-010 ENSP00000452525 ENST00000555615	G3V5U3 [Direct mapping] Calmin Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	101 aa 10.9 kDa	No	0