Expression of PDZRN4 in cancer - Summary - The Human Protein Atlas

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PDZRN4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDZRN4
Gene description	PDZ domain containing ring finger 4
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enriched (U-266/70)
HPA (normal tissue):	Tissue enhanced (seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA039510
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039510

GENE INFORMATION
Gene name	PDZRN4 (HGNC Symbol)
Synonyms	DKFZp434B0417, FLJ33777, IMAGE5767589, LNX4
Description	PDZ domain containing ring finger 4 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q12
Chromosome location (bp)	41188448 - 41574590
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165966 (version 83.38)
Entrez gene	29951
UniProt	Q6ZMN7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZMN7
Antibodypedia	PDZRN4 antibodies

PROTEIN BROWSER

PDZRN4-001	PDZRN4-002	PDZRN4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDZRN4-001 ENSP00000384197 ENST00000402685	Q6ZMN7 [Direct mapping] PDZ domain-containing RING finger protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	1036 aa 117.1 kDa	No	0
PDZRN4-002 ENSP00000439990 ENST00000539469	Q6ZMN7 [Direct mapping] PDZ domain-containing RING finger protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	778 aa 89.1 kDa	No	0
PDZRN4-003 ENSP00000298919 ENST00000298919	Q6ZMN7 [Direct mapping] PDZ domain-containing RING finger protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] Show all	776 aa 88.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.