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SLC6A5

GENERAL INFORMATION

Gene name

 SLC6A5

Gene description

 Solute carrier family 6 (neurotransmitter transporter), member 5

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (lung)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SLC6A5 (HGNC Symbol)

Synonyms

 GLYT2, NET1

Description

 Solute carrier family 6 (neurotransmitter transporter), member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. [provided by RefSeq, Oct 2009]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 20599400 - 20659285

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165970 (version 83.38)

Entrez gene

 9152

UniProt

 Q9Y345 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y345

Antibodypedia

 SLC6A5 antibodies

PROTEIN BROWSER
SLC6A5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A5-001
ENSP00000434364
ENST00000525748
Q9Y345 [Direct mapping]
Sodium- and chloride-dependent glycine transporter 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006836 [neurotransmitter transport]
GO:0007268 [synaptic transmission]
GO:0015375 [glycine:sodium symporter activity]
GO:0016021 [integral component of membrane]
GO:0036233 [glycine import]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
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 797 aa
87.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.