We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
KCNC2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

KCNC2

Gene description

Potassium channel, voltage gated Shaw related subfamily C, member 2

Protein class

FDA approved drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (breast cancer, prostate cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 2 antibodies.
HPA019664 , CAB022571
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (breast cancer, prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA019664
CAB022571

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A majority of malignant cells were weakly stained or negative. Most endometrial cancers along with several cases of ovarian cancers and malignant melanomas showed moderate cytoplasmic immunoreactivity.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Moderate immunoreactivity was observed in most liver and renal cancers as well as several urothelial and gastric cancers cancers. Malignant cells in general showed weak staining or were negative.

GENE INFORMATION

Gene name

KCNC2 (HGNC Symbol)

Synonyms

Kv3.2

Description

Potassium channel, voltage gated Shaw related subfamily C, member 2 (HGNC Symbol)

Entrez gene summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

q21.1

Chromosome location (bp)

75040077 - 75209868

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166006 (version 83.38)

Entrez gene

3747

UniProt

Q96PR1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96PR1

Antibodypedia

KCNC2 antibodies

PROTEIN BROWSER

KCNC2-001
KCNC2-002
KCNC2-003
KCNC2-004
KCNC2-005
KCNC2-006
KCNC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNC2-001
ENSP00000449253
ENST00000549446
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBA5 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_a
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009636 [response to toxic substance]
GO:0009642 [response to light intensity]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0021759 [globus pallidus development]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030673 [axolemma]
GO:0031982 [vesicle]
GO:0032026 [response to magnesium ion]
GO:0032809 [neuronal cell body membrane]
GO:0034220 [ion transmembrane transport]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071242 [cellular response to ammonium ion]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0097237 [cellular response to toxic substance]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1990089 [response to nerve growth factor]
Show all
638 aa
70.2 kDa
No 6
KCNC2-002
ENSP00000376966
ENST00000393288
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
618 aa
68.3 kDa
No 6
KCNC2-003
ENSP00000438423
ENST00000540018
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
583 aa
64.3 kDa
No 6
KCNC2-004
ENSP00000319877
ENST00000350228
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
558 aa
61.6 kDa
No 6
KCNC2-005
ENSP00000448301
ENST00000550433
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBF2 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_b
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
629 aa
69.5 kDa
No 6
KCNC2-006
ENSP00000449941
ENST00000548513
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBE3 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_d
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
613 aa
67.6 kDa
No 6
KCNC2-201
ENSP00000298972
ENST00000298972
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBE3 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_d
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
613 aa
67.6 kDa
No 6

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.