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KCNC2

GENERAL INFORMATION

Gene name

 KCNC2

Gene description

 Potassium channel, voltage gated Shaw related subfamily C, member 2

Protein class

 FDA approved drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, prostate cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA019664 , CAB022571
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019664
CAB022571

GENE INFORMATION

Gene name

 KCNC2 (HGNC Symbol)

Synonyms

 Kv3.2

Description

 Potassium channel, voltage gated Shaw related subfamily C, member 2 (HGNC Symbol)

Entrez gene summary

 The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 12

Cytoband

 q21.1

Chromosome location (bp)

 75040077 - 75209868

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166006 (version 83.38)

Entrez gene

 3747

UniProt

 Q96PR1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PR1

Antibodypedia

 KCNC2 antibodies

PROTEIN BROWSER
KCNC2-001
KCNC2-002
KCNC2-003
KCNC2-004
KCNC2-005
KCNC2-006
KCNC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNC2-001
ENSP00000449253
ENST00000549446
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBA5 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_a
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009636 [response to toxic substance]
GO:0009642 [response to light intensity]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0021759 [globus pallidus development]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030673 [axolemma]
GO:0031982 [vesicle]
GO:0032026 [response to magnesium ion]
GO:0032809 [neuronal cell body membrane]
GO:0034220 [ion transmembrane transport]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071242 [cellular response to ammonium ion]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0097237 [cellular response to toxic substance]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1990089 [response to nerve growth factor]
Show all
 638 aa
70.2 kDa 		No 6
KCNC2-002
ENSP00000376966
ENST00000393288
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
 618 aa
68.3 kDa 		No 6
KCNC2-003
ENSP00000438423
ENST00000540018
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
 583 aa
64.3 kDa 		No 6
KCNC2-004
ENSP00000319877
ENST00000350228
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
 558 aa
61.6 kDa 		No 6
KCNC2-005
ENSP00000448301
ENST00000550433
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBF2 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_b
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
 629 aa
69.5 kDa 		No 6
KCNC2-006
ENSP00000449941
ENST00000548513
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBE3 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_d
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
 613 aa
67.6 kDa 		No 6
KCNC2-201
ENSP00000298972
ENST00000298972
Q96PR1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 2
A0A024RBE3 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shaw-related subfamily, member 2, isoform CRA_d
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0038060 [nitric oxide-cGMP-mediated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
Show all
 613 aa
67.6 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.