Expression of TCP11L2 in cancer - Summary - The Human Protein Atlas

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TCP11L2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TCP11L2
Gene description	T-complex 11, testis-specific-like 2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA039483 , HPA042188
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039483	HPA042188

GENE INFORMATION
Gene name	TCP11L2 (HGNC Symbol)
Synonyms	MGC40368
Description	T-complex 11, testis-specific-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	106301929 - 106347015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166046 (version 83.38)
Entrez gene	255394
UniProt	Q8N4U5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N4U5
Antibodypedia	TCP11L2 antibodies

PROTEIN BROWSER

TCP11L2-001	TCP11L2-002	TCP11L2-003	TCP11L2-004	TCP11L2-005	TCP11L2-006	TCP11L2-007	TCP11L2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCP11L2-001 ENSP00000299045 ENST00000299045	Q8N4U5 [Direct mapping] T-complex protein 11-like protein 2 A0A024RBH4 [Target identity:100%; Query identity:100%] T-complex 11 (Mouse) like 2, isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		519 aa 58.1 kDa	No	0
TCP11L2-002 ENSP00000448952 ENST00000547153	Q8N4U5 [Direct mapping] T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		266 aa 29.9 kDa	No	0
TCP11L2-003 ENSP00000447416 ENST00000553143	F8VW27 [Direct mapping] T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2 kDa	No	0
TCP11L2-004 ENSP00000449123 ENST00000546625	G3V1Z2 [Direct mapping] T-complex 11 (Mouse) like 2, isoform CRA_c; T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		272 aa 30.9 kDa	No	0
TCP11L2-005 ENSP00000447457 ENST00000548428	F8W1M6 [Direct mapping] T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.6 kDa	No	0
TCP11L2-006 ENSP00000449844 ENST00000551228	F8VW27 [Direct mapping] T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2 kDa	No	0
TCP11L2-007 ENSP00000448629 ENST00000553098	F8VRQ3 [Direct mapping] T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		234 aa 26.1 kDa	No	0
TCP11L2-009 ENSP00000447174 ENST00000551802	F8W0R5 [Direct mapping] T-complex protein 11-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.