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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SPRED1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SPRED1

Gene description

Sprouty-related, EVH1 domain containing 1

Protein class

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA042193
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Stomach cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA042193

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas along with several testicular seminomas, gliomas and melanomas showed moderate cytoplasmic immunoreactivity. Cancers in general were weakly stained or negative.

GENE INFORMATION

Gene name

SPRED1 (HGNC Symbol)

Synonyms

FLJ33903, PPP1R147

Description

Sprouty-related, EVH1 domain containing 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q14

Chromosome location (bp)

38252326 - 38357249

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166068 (version 83.38)

Entrez gene

161742

UniProt

Q7Z699 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z699

Antibodypedia

SPRED1 antibodies

PROTEIN BROWSER

SPRED1-001
SPRED1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPRED1-001
ENSP00000299084
ENST00000299084
Q7Z699 [Direct mapping]
Sprouty-related, EVH1 domain-containing protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000188 [inactivation of MAPK activity]
GO:0005173 [stem cell factor receptor binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009966 [regulation of signal transduction]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0090311 [regulation of protein deacetylation]
Show all
444 aa
50.5 kDa
No 1
SPRED1-003
ENSP00000453680
ENST00000561317
H0YMN8 [Direct mapping]
Sprouty-related, EVH1 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
131 aa
14.6 kDa
No 0

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