Expression of SVOP in cancer - Summary - The Human Protein Atlas

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SVOP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SVOP
Gene description	SV2 related protein
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Cell line enhanced (Karpas-707, RPMI-8226, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA016573
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016573

GENE INFORMATION
Gene name	SVOP (HGNC Symbol)
Synonyms	DKFZp761H039
Description	SV2 related protein (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	108907741 - 109021240
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166111 (version 83.38)
Entrez gene	55530
UniProt	Q8N4V2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N4V2
Antibodypedia	SVOP antibodies

PROTEIN BROWSER

SVOP-001	SVOP-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SVOP-001 ENSP00000479104 ENST00000610966	Q8N4V2 [Direct mapping] Synaptic vesicle 2-related protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0008021 [synaptic vesicle] GO:0015075 [ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	548 aa 60.8 kDa	No	>9
SVOP-003 ENSP00000447275 ENST00000546618	H0YHK4 [Direct mapping] Synaptic vesicle 2-related protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	156 aa 17.1 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.