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AVPR1A

GENERAL INFORMATION

Gene name

 AVPR1A

Gene description

 Arginine vasopressin receptor 1A

Protein class

 FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (Karpas-707, U-266/84)
HPA (normal tissue):Tissue enhanced (adrenal gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 AVPR1A (HGNC Symbol)

Synonyms

 AVPR1

Description

 Arginine vasopressin receptor 1A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q14.2

Chromosome location (bp)

 63142759 - 63150942

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166148 (version 83.38)

Entrez gene

 552

UniProt

 P37288 (UniProt - Evidence at protein level)

neXtProt

 NX_P37288

Antibodypedia

 AVPR1A antibodies

PROTEIN BROWSER
AVPR1A-001
AVPR1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AVPR1A-001
ENSP00000299178
ENST00000299178
P37288 [Direct mapping]
Vasopressin V1a receptor
X5D2B0 [Target identity:100%; Query identity:100%]
Vasopressin V1a receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
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GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0002125 [maternal aggressive behavior]
GO:0003084 [positive regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006091 [generation of precursor metabolites and energy]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007621 [negative regulation of female receptivity]
GO:0007625 [grooming behavior]
GO:0008015 [blood circulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010033 [response to organic substance]
GO:0010035 [response to inorganic substance]
GO:0010460 [positive regulation of heart rate]
GO:0014049 [positive regulation of glutamate secretion]
GO:0014902 [myotube differentiation]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019722 [calcium-mediated signaling]
GO:0021537 [telencephalon development]
GO:0030307 [positive regulation of cell growth]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0031410 [cytoplasmic vesicle]
GO:0031894 [V1A vasopressin receptor binding]
GO:0032849 [positive regulation of cellular pH reduction]
GO:0032870 [cellular response to hormone stimulus]
GO:0035176 [social behavior]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042277 [peptide binding]
GO:0042631 [cellular response to water deprivation]
GO:0042711 [maternal behavior]
GO:0042713 [sperm ejaculation]
GO:0043084 [penile erection]
GO:0045777 [positive regulation of blood pressure]
GO:0045907 [positive regulation of vasoconstriction]
GO:0051412 [response to corticosterone]
GO:0051970 [negative regulation of transmission of nerve impulse]
GO:1901652 [response to peptide]
Show all
 418 aa
46.8 kDa 		No 7
AVPR1A-002
ENSP00000449822
ENST00000550940
F8VW98 [Direct mapping]
Vasopressin V1a receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0042711 [maternal behavior]
GO:0045907 [positive regulation of vasoconstriction]
GO:1901652 [response to peptide]
Show all
 186 aa
20.9 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.