Expression of SENP8 in cancer - Summary - The Human Protein Atlas

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SENP8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SENP8
Gene description	SUMO/sentrin peptidase family member, NEDD8 specific
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036273
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036273

GENE INFORMATION
Gene name	SENP8 (HGNC Symbol)
Synonyms	DEN1, HsT17512, NEDP1, PRSC2
Description	SUMO/sentrin peptidase family member, NEDD8 specific (HGNC Symbol)
Entrez gene summary	This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Chromosome	15
Cytoband	q23
Chromosome location (bp)	72114258 - 72143688
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166192 (version 83.38)
Entrez gene	123228
UniProt	Q96LD8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96LD8
Antibodypedia	SENP8 antibodies

PROTEIN BROWSER

SENP8-001	SENP8-002	SENP8-003	SENP8-004	SENP8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SENP8-001 ENSP00000340505 ENST00000340912	Q96LD8 [Direct mapping] Sentrin-specific protease 8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0019784 [NEDD8-specific protease activity] Show all	212 aa 24.1 kDa	No	0
SENP8-002 ENSP00000446057 ENST00000542035	Q96LD8 [Direct mapping] Sentrin-specific protease 8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0019784 [NEDD8-specific protease activity] Show all	212 aa 24.1 kDa	No	0
SENP8-003 ENSP00000457208 ENST00000567794	H3BTJ8 [Direct mapping] Sentrin-specific protease 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	37 aa 4.2 kDa	No	0
SENP8-004 ENSP00000456567 ENST00000564863	H3BS71 [Direct mapping] Sentrin-specific protease 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	73 aa 8.3 kDa	No	0
SENP8-005 ENSP00000457215 ENST00000564082	H3BTK5 [Direct mapping] Sentrin-specific protease 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0019784 [NEDD8-specific protease activity] Show all	130 aa 14.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.