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SCN3B

GENERAL INFORMATION

Gene name

 SCN3B

Gene description

 Sodium channel, voltage gated, type III beta subunit

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (hTCEpi, RH-30, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SCN3B (HGNC Symbol)

Synonyms

 HSA243396

Description

 Sodium channel, voltage gated, type III beta subunit (HGNC Symbol)

Entrez gene summary

 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q24.1

Chromosome location (bp)

 123629187 - 123655244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166257 (version 83.38)

Entrez gene

 55800

UniProt

 Q9NY72 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NY72

Antibodypedia

 SCN3B antibodies

PROTEIN BROWSER
SCN3B-001
SCN3B-002
SCN3B-003
SCN3B-004
SCN3B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCN3B-001
ENSP00000376523
ENST00000392770
Q9NY72 [Direct mapping]
Sodium channel subunit beta-3
A0A024R3H7 [Target identity:100%; Query identity:100%]
Sodium channel, voltage-gated, type III, beta, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006814 [sodium ion transport]
GO:0007399 [nervous system development]
GO:0010460 [positive regulation of heart rate]
GO:0010765 [positive regulation of sodium ion transport]
GO:0016021 [integral component of membrane]
GO:0017080 [sodium channel regulator activity]
GO:0019233 [sensory perception of pain]
GO:0030018 [Z disc]
GO:0035725 [sodium ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0051899 [membrane depolarization]
GO:0060048 [cardiac muscle contraction]
GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization]
GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization]
GO:0061337 [cardiac conduction]
GO:0072659 [protein localization to plasma membrane]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086010 [membrane depolarization during action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 215 aa
24.7 kDa 		Yes 1
SCN3B-002
ENSP00000432785
ENST00000530277
Q9NY72 [Direct mapping]
Sodium channel subunit beta-3
A0A024R3H7 [Target identity:100%; Query identity:100%]
Sodium channel, voltage-gated, type III, beta, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006814 [sodium ion transport]
GO:0010460 [positive regulation of heart rate]
GO:0010765 [positive regulation of sodium ion transport]
GO:0016021 [integral component of membrane]
GO:0017080 [sodium channel regulator activity]
GO:0030018 [Z disc]
GO:0035725 [sodium ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0051899 [membrane depolarization]
GO:0060048 [cardiac muscle contraction]
GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization]
GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization]
GO:0072659 [protein localization to plasma membrane]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086010 [membrane depolarization during action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 215 aa
24.7 kDa 		Yes 1
SCN3B-003
ENSP00000434363
ENST00000528267
E9PQS8 [Direct mapping]
Sodium channel subunit beta-3
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0006814 [sodium ion transport]
GO:0017080 [sodium channel regulator activity]
Show all
 93 aa
10.8 kDa 		Yes 0
SCN3B-004
ENSP00000435554
ENST00000527836
E9PJP6 [Direct mapping]
Sodium channel subunit beta-3
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005515 [protein binding]
GO:0006814 [sodium ion transport]
GO:0017080 [sodium channel regulator activity]
Show all
 141 aa
16.3 kDa 		Yes 0
SCN3B-201
ENSP00000299333
ENST00000299333
Q9NY72 [Direct mapping]
Sodium channel subunit beta-3
A0A024R3H7 [Target identity:100%; Query identity:100%]
Sodium channel, voltage-gated, type III, beta, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006814 [sodium ion transport]
GO:0010460 [positive regulation of heart rate]
GO:0010765 [positive regulation of sodium ion transport]
GO:0016021 [integral component of membrane]
GO:0017080 [sodium channel regulator activity]
GO:0030018 [Z disc]
GO:0035725 [sodium ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0051899 [membrane depolarization]
GO:0060048 [cardiac muscle contraction]
GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization]
GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization]
GO:0072659 [protein localization to plasma membrane]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086010 [membrane depolarization during action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 215 aa
24.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.