Expression of FAM227B in cancer - Summary - The Human Protein Atlas

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FAM227B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM227B
Gene description	Family with sequence similarity 227, member B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA049774
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049774

GENE INFORMATION
Gene name	FAM227B (HGNC Symbol)
Synonyms	C15orf33, FLJ32800
Description	Family with sequence similarity 227, member B (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	49326962 - 49620931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166262 (version 83.38)
Entrez gene	196951
UniProt	Q96M60 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96M60
Antibodypedia	FAM227B antibodies

PROTEIN BROWSER

FAM227B-001	FAM227B-002	FAM227B-004	FAM227B-006	FAM227B-008	FAM227B-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM227B-001 ENSP00000299338 ENST00000299338	Q96M60 [Direct mapping] Protein FAM227B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		508 aa 60 kDa	No	0
FAM227B-002 ENSP00000453028 ENST00000561064	Q96M60 [Direct mapping] Protein FAM227B Show all	Predicted intracellular proteins Show all		304 aa 36.3 kDa	No	0
FAM227B-004 ENSP00000452616 ENST00000558594	H0YK12 [Direct mapping] Protein FAM227B Show all	Predicted intracellular proteins Show all		166 aa 19.8 kDa	No	0
FAM227B-006 ENSP00000453379 ENST00000559905	H0YLX5 [Direct mapping] Protein FAM227B Show all	Predicted intracellular proteins Show all		182 aa 21.9 kDa	No	0
FAM227B-008 ENSP00000454081 ENST00000560246	H0YNN2 [Direct mapping] Protein FAM227B Show all	Predicted intracellular proteins Show all		178 aa 21.2 kDa	No	0
FAM227B-011 ENSP00000453787 ENST00000558579	H0YMX9 [Direct mapping] Protein FAM227B Show all	Predicted intracellular proteins Show all		134 aa 16 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.