Expression of SYNPO2L in cancer - Summary - The Human Protein Atlas

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SYNPO2L

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SYNPO2L
Gene description	Synaptopodin 2-like
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, head and neck cancer, prostate cancer)
HPA (cell line):	Cell line enhanced (CACO-2, RH-30, SK-BR-3)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA055192 , HPA057142
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, head and neck cancer, prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055192	HPA057142

GENE INFORMATION
Gene name	SYNPO2L (HGNC Symbol)
Synonyms	FLJ12921
Description	Synaptopodin 2-like (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q22.2
Chromosome location (bp)	73644881 - 73663803
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166317 (version 83.38)
Entrez gene	79933
UniProt	Q9H987 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H987
Antibodypedia	SYNPO2L antibodies

PROTEIN BROWSER

SYNPO2L-001	SYNPO2L-003	SYNPO2L-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNPO2L-001 ENSP00000361964 ENST00000372873	Q9H987 [Direct mapping] Synaptopodin 2-like protein A0A024QZQ8 [Target identity:100%; Query identity:100%] Synaptopodin 2-like, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005856 [cytoskeleton] Show all	753 aa 79.1 kDa	No	0
SYNPO2L-003 ENSP00000378289 ENST00000394810	Q9H987 [Direct mapping] Synaptopodin 2-like protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0030018 [Z disc] Show all	977 aa 102.5 kDa	No	0
SYNPO2L-004 ENSP00000475768 ENST00000606523	U3KQD0 [Direct mapping] Synaptopodin 2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.