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ILK

GENERAL INFORMATION

Gene name

 ILK

Gene description

 Integrin-linked kinase

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most organs, with highest abundance in muscle tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
CAB004041
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB004041

GENE INFORMATION

Gene name

 ILK

Synonyms

Description

 Integrin-linked kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 6603708 - 6610874

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166333 (version 83.38)

Entrez gene

 3611

UniProt

 Q13418 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13418

Antibodypedia

 ILK antibodies

PROTEIN BROWSER
ILK-001
ILK-002
ILK-003
ILK-004
ILK-005
ILK-013
ILK-201
ILK-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ILK-001
ENSP00000299421
ENST00000299421
Q13418 [Direct mapping]
Integrin-linked protein kinase
V9HWF0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 28
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 452 aa
51.4 kDa 		No 0
ILK-002
ENSP00000403487
ENST00000420936
Q13418 [Direct mapping]
Integrin-linked protein kinase
V9HWF0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 28
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 452 aa
51.4 kDa 		No 0
ILK-003
ENSP00000379975
ENST00000396751
Q13418 [Direct mapping]
Integrin-linked protein kinase
V9HWF0 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 28
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001725 [stress fiber]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0003151 [outflow tract morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007050 [cell cycle arrest]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007569 [cell aging]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010761 [fibroblast migration]
GO:0014044 [Schwann cell development]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0021675 [nerve development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030054 [cell junction]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0032288 [myelin assembly]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0043025 [neuronal cell body]
GO:0043034 [costamere]
GO:0043066 [negative regulation of apoptotic process]
GO:0043195 [terminal bouton]
GO:0043198 [dendritic shaft]
GO:0043206 [extracellular fibril organization]
GO:0043234 [protein complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050772 [positive regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0051291 [protein heterooligomerization]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 452 aa
51.4 kDa 		No 0
ILK-004
ENSP00000439606
ENST00000537806
A0A0A0MTH3 [Direct mapping]
Integrin-linked protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 483 aa
54.6 kDa 		No 0
ILK-005
ENSP00000435323
ENST00000528995
Q13418 [Direct mapping]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 391 aa
44.3 kDa 		No 0
ILK-013
ENSP00000480597
ENST00000526318
A0A087WWY6 [Direct mapping]
Integrin-linked protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 111 aa
12.5 kDa 		No 0
ILK-201
ENSP00000434492
ENST00000532063
Q13418 [Direct mapping]
Integrin-linked protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030017 [sarcomere]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0042327 [positive regulation of phosphorylation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070527 [platelet aggregation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 318 aa
36.5 kDa 		No 0
ILK-202
ENSP00000487498
ENST00000627400
E9PQ52 [Direct mapping]
Integrin-linked protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 36 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.