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DCHS1

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GENERAL INFORMATION

Gene name

 DCHS1

Gene description

 Dachsous cadherin-related 1

Protein class

 Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Cell line enhanced (HUVEC TERT2, SH-SY5Y, AF22, REH)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA017970
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, SH-SY5Y, AF22, REH)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA017970 AF22 Plasma membrane
HPA017970 HUVEC TERT2 Plasma membrane

GENE INFORMATION

Gene name

 DCHS1 (HGNC Symbol)

Synonyms

 CDH25, CDHR6, FIB1, FLJ11790, KIAA1773, PCDH16

Description

 Dachsous cadherin-related 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 6621323 - 6655854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166341 (version 83.38)

Entrez gene

 8642

UniProt

 Q96JQ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96JQ0

Antibodypedia

 DCHS1 antibodies

PROTEIN BROWSER
DCHS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCHS1-001
ENSP00000299441
ENST00000299441
Q96JQ0 [Direct mapping]
Protocadherin-16
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001822 [kidney development]
GO:0003007 [heart morphogenesis]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0021915 [neural tube development]
GO:0022008 [neurogenesis]
GO:0035329 [hippo signaling]
GO:0036342 [post-anal tail morphogenesis]
GO:0043931 [ossification involved in bone maturation]
GO:0045177 [apical part of cell]
GO:0048565 [digestive tract development]
GO:0090102 [cochlea development]
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 3298 aa
346.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.