Expression of C11orf74 in cancer - Summary - The Human Protein Atlas

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C11orf74

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C11orf74
Gene description	Chromosome 11 open reading frame 74
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044880
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA044880

GENE INFORMATION
Gene name	C11orf74 (HGNC Symbol)
Synonyms	FLJ38678, HEPIS
Description	Chromosome 11 open reading frame 74 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Chromosome	11
Cytoband	p12
Chromosome location (bp)	36594493 - 36659290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166352 (version 83.38)
Entrez gene	119710
UniProt	Q86VG3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86VG3
Antibodypedia	C11orf74 antibodies

PROTEIN BROWSER

C11orf74-001	C11orf74-002	C11orf74-003	C11orf74-004	C11orf74-006	C11orf74-007	C11orf74-008	C11orf74-201	C11orf74-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C11orf74-001 ENSP00000334848 ENST00000334307	Q86VG3 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		221 aa 25.4 kDa	No	0
C11orf74-002 ENSP00000299442 ENST00000347206	Q86VG3 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		147 aa 16.8 kDa	No	0
C11orf74-003 ENSP00000433152 ENST00000534635	Q86VG3 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		147 aa 16.8 kDa	No	0
C11orf74-004 ENSP00000431374 ENST00000532470	Q86VG3 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		221 aa 25.4 kDa	No	0
C11orf74-006 ENSP00000433407 ENST00000531554	E9PL16 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		180 aa 20.6 kDa	No	0
C11orf74-007 ENSP00000432685 ENST00000530697	E9PPH4 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		83 aa 9.6 kDa	No	0
C11orf74-008 ENSP00000435676 ENST00000527108	E9PJ48 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		90 aa 10.2 kDa	No	0
C11orf74-201 ENSP00000403937 ENST00000446510	Q86VG3 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		221 aa 25.4 kDa	No	0
C11orf74-202 ENSP00000483671 ENST00000617650	Q86VG3 [Direct mapping] Uncharacterized protein C11orf74 Show all	Predicted intracellular proteins Show all		221 aa 25.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.