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RNA cell line category: Group enriched (SH-SY5Y, HeLa, SCLC-21H, SiHa)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
LMO1 (HGNC Symbol)
Synonyms
RBTN1, RHOM1, TTG1
Description
LIM domain only 1 (rhombotin 1) (HGNC Symbol)
Entrez gene summary
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046013 [regulation of T cell homeostatic proliferation]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes
Show all
GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
